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Y. Shi, P. Hu, H. Ye, X. Qiu

 Department of Chemical Engineering, Tsinghua University, Beijing, China

Keywords: PHBV, PHB, rifampin, electrospun, drug delivery

Polymeric drug delivery systems have numerous advantages compared with conventional dosage forms, such as improved therapeutic effect, reduced toxicity, convenience, and so on. PHAs are thought to be a sort of good natural biodegraded polymer used for drug delivery systems. Electrospun was an efficacious way of preparing nano- or micro- fibers. It was reported that drugs can be capsulated directly into electrospun fibers and these systems showed nearly zero-order kinetics of drug release. The use of drug delivery systems in electrospun fibers will be expected in biomedical applications and tissue engineering in the near future. [1-5]

In this paper, the influences of solvent, medical drugs and electrospun parameter like voltage, distance, etc. on the diameter size and uniformity of electrospun PHBV and PHB fibers were examined by changing the solvent, adding medicine rifampin and shifting the electrospun parameter in the electrospun process. SEM, TGA, DSC, drug release and other experiments were done to evaluate the properties of the electrospun fiber.

[1]       Geert Verreck et al., 2003. J. Controlled Release 92, 349-360.

[2]       Jing Zeng et al., 2003. J. Controlled Release 92, 227-231.

[3]       Greet Verreck et al., 2003. Pharm. Res. 20, 810-817.

[4]       El-Refaie Kenawy et al., 2002. J. Controlled Release 81, 57-64.

Zheng-Ming Huang et al., 2003. Composites Science and Technology 63, 2223-2253.

       論文來源：International Symposium on Biological Polyesters ,Auguest 22-27, 2004