Drug release property of a pH-responsive double-hydrophilic hyperbranched graft copolymer
作者：Sun, X. Y.; Zhou, Y. F.*; Yan, D. Y.*
關鍵字：hyperbranched polymers, double-hydrophilic copolymer, polyglycerol, ATRP, drug delivery
論文來源：期刊
具體來源：Sci. China Ser. B-Chem. 2009, 52, 1703. http://link.springer.com/article/10.1007/s11426-009-0227-4
發表時間：2009年
In this paper, we report the synthesis and self-assembly of double-hydrophilic hyperbranched graft copolymers of HPG-
g-PDMAEMA,
which consist of a hyperbranched polyglycerol (HPG) core and several
grafted poly(2-(dimethylamino)ethyl methacrylate) (PDMAEMA) arms. HPG
was synthesized by cationic polymerization. Then HPG-Br macroinitiator
was obtained by esterification of HPG with 2-bromoisobutyryl bromide,
which was subsequently used in the preparation of HPG-
g-PDMAEMA graft copolymers through atom transfer radical polymerization (
ATRP) of DMAEMA monomers. The molecular structures were studied by
1H NMR and GPC. The pyrene-based fluorescent probe method,
1H NMR and DLS were used to study the self-assembly behavior of HPG-
g-PDMAEMA. The drug loading and pH-responsive release properties of HPG-
g-PDMAEMA were also investigated by using coumarin 102 as a model drug. The results show that the HPG-
g-PDMAEMA
micelles can continuously release and re-encapsulate coumarin 102 as
the pH continuously changes from 11.5 to 2.5; however, this process is
not totally reversible.