Flocculation-Resistant Multimolecular Micelles with Thermo-Responsive Corona from Dendritic Heteroarm Star Copolymers
作者：(30) Zheng, Y. L.; Zhong, L.; Huang, W.; Zhou, Y. F.*; Yan, D. Y.
關鍵字：dendritic heteroarm star copolymers, drug delivery systems, drug release, LCST, micelles, reversible addition-fragmentation chain transfer (RAFT), thermoresponsive
論文來源：期刊
具體來源：J. Polym. Sci., Part A: Polym. Chem. 2010, 48, 4428. http://onlinelibrary.wiley.com/doi/10.1002/pola
發表時間：2010年
In this article, we report the self-assembly of flocculation-resistant
multimolecular micelles with thermoresponsive corona from novel
dendritic heteroarm star copolymers. The micelles have a
core-shell-corona structure at room temperature according to pyrene
probe fluorescence spectrometry, proton nuclear magnetic resonance (1H
NMR), transmission electron microscopy, and dynamic light scattering
measurements. Increasing the temperature above the lower critical
solution temperature (LCST), the micelles show high
flocculation-resistant ability resulting from a structure transition
from core-shell-corona to core-shell confirmed by a quantitative
variable temperature 1H NMR analysis method using potassium
hydrogen phthalate as an external standard. A big volume change of the
micelles is observed during the LCST transition. The drug loading and
temperature-dependent release properties of the micelles are also
investigated by using coumarin 102 as a model drug, which displays a
rapid drug release at a temperature above the LCST. © 2010 Wiley
Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2010