11. Synthesis and physicochemical characterization of a novel amphiphilic polylactic acid-hyperbranched polyglycerol conjugate for protein drug delivery.
作者：Xiujun Gao, Xinge Zhang*, Zhongming Wu, Xuejiao Zhang, Zhen Wang, Chaoxing Li*
關(guān)鍵字：hyperbranched polyglycerol
論文來源：期刊
具體來源：Journal of Controlled Release, 2009, 140:141-147.
發(fā)表時間：2009年
Amphiphilic copolymers with polylactic acid (PLA) chains grafted onto hyperbranched polyglycerol (HPG) have been synthesized and characterized. The copolymer nanoparticles with corona and core structure were formed by self-assembly in aqueous solution. The loading capacity and association efficiency were up to 23% and 86%, respectively. Protein release profiles with different copolymer compositions and BSA concentrations all showed a burst effect followed by a continuous release phase. The released BSA from the copolymer nanoparticles remained in its original structure over a period of 4 days, as testified by circular dichroism spectroscopy. Furthermore, cell viability research suggested good biocompatibility of the copolymer nanoparticles, which have a promising potential for protein delivery system.