writer：張黎明等 // Zhang, L. M.; et al
keywords：天然大分子，生物大分子, 功能材料, 雜化材料 // Natural macromolecules, Biomacromolecules, Functional materials, Hybrid materials
source：期刊
Issue time：2026年
*Corresponding author(s)/通訊作者. #These authors contributed equally to this work/共同第一作者.
[384] Yang, H. K.; Zhang, L. M. * Preparation, self-assembly, loading drug, blood clotting and hemolysis of amphiphilic diblock copolymers based on α-alkyne poly(ε-benzyloxycarbonyl-L-lysine) and α-azido heparin. Colloids and Surfaces A-Physicochemical and Engineering Aspects, 2026, incomplete submission.
[383] Deng, J. J.#; Chen, S. S.#.; Li, N.#; Zhou, J. Y.; Lao, G. J.; Ren, M.; Yang, C.; Yan, L.*; Zhang, L. M.*Amphiphilic beta-cyclodextrin-centered heteroarm star polymers toward the co-delivery of methotrexate and plasmid DNA. Journal of Biomaterials Science, Polymer Edition, 2026, incomplete submission.
[382] Zhang, J. Z. #; Liang, H. S. #; Mao, X. H.; Wang, F.*; Huang, L. L.*; Zhang, L. M.* Gene delivery therapy and photothermal therapy of osteosarcoma via multifunctional spermine-modified amylose@IR-780 nanocomplexes. Journal of Colloid and Interface Science, 2026, incomplete submission.
[381] Zheng, X.; Zhou, J. Y.; Wang, H. Z.; Lu, B.; Lai, J. Y.; Guo, S.-Z.*; Zhang, L. M.* Dual-Modality Cancer Therapy via Light-Triggered CO Release and Photothermal Effects from Engineered Prussian Blue Nanoparticles. Advanced Healthcare Materials, 2026, Manuscript Status_Submitted.
[380] Wang, H. Z.; Lu, B.; Zhou, J. Y.; Xia, H. J.; Guo, S.-Z.*; Zhang, L. M.* Dynamic Biomass-Based Hydrogel with Dual pH/Glucose Responsiveness for Controlled Nitric Oxide Release and Diabetic Wound Healing. Biomacromolecules, 2026, Manuscript Status_Submitted..
[379] Lu, B.; Zhou, J. Y.; Wang, H. Z.; Lai, J. Y.; Zheng, X.; Guo, S.-Z.*; Zhang, L. M.* Intelligent ROS-triggered NO and isotretinoin co-delivery hydrogel dressings for microenvironment modulation and rapid repair of diabetic wounds. Chemical Engineering Journal, 2026, In Revision.
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[學術會議/Scientific Conferences-160] 陸濱，王含章，郭雙壯*，張黎明*. 新型智能水凝膠用于糖尿病傷口 (墻報). 中國化學會第35屆學術年會, 2026年4月11日至14日在重慶市舉行，4月10日報到。 https://www.chemsoc.org.cn/meeting/35th/
摘要：糖尿病慢性創面因長期炎癥反應、細菌感染以及組織再生能力受損而難以愈合，仍是亟待解決的臨床問題。本研究構建了一種活性氧響應型一氧化氮釋放水凝膠體系，以三羥甲基氨基甲烷改性的透明質酸為基體，引入具有天然抗菌活性的 ε-聚賴氨酸，并結合功能化中空介孔雜化二氧化硅納米顆粒，實現藥物負載與刺激響應釋放。該水凝膠可在溫和條件下快速凝膠化，形成穩定三維網絡結構，表現出良好的組織黏附性能、抗菌活性及促愈合潛能。通過結構與功能模塊的理性設計，材料在氧化應激條件下可實現異維A酸的可控釋放，并進一步觸發按需 NO 生成。體內外實驗表明，異維A酸與 NO 的釋放均呈 ROS 水平依賴性且具可調控特征，從而顯著促進創面閉合，增強膠原沉積與血管新生，并改善局部炎癥微環境。該水凝膠體系具有良好的生物相容性與智能響應特性，提示其作為多功能創面敷料在糖尿病慢性創面高效治療中具有潛在應用價值。