主要譯著者：Liqun Yang, Li-Ming Zhang
出版機構：New York: Nova Science Publishers
Liqun Yang, Li-Ming Zhang. Polysaccharides and Their Derivatives for Biomedical Applications. In: Handbook of Carbohydrate Polymers: Development, Properties and Applications (edited by Ryouichi Ito and Youta Matsuo Eds). New York: Nova Science Publishers, 2010, pp.693-709 (Invited Book Chapter) (ISBN: 978-1-60876-367-2).
Abstract:
Polysaccharides
are one of essential biomacromolecules in nature, which play important roles in
life activities. Some of them exhibit various biological activities or have
special functions. Moreover, polysaccharides contain reactive groups, such as
hydroxyl, amino and carboxylic acid groups. Thus, they may react with some
compounds to produce polysaccharide derivatives. Amphiphilic polysaccharide
derivatives can selfassemble into stable micelles in aqueous solution,
promising as a new carrier for the controlled release of drugs. In order to
overcome various barriers which hinder drug delivery, the drug molecules may be
conjugated with polysaccharide chains through chemical bonds to form prodrugs.
The parent drug can be released through an enzymatic or chemical transformation
during the metabolizing process. This article reviews the investigations of
bioactive and functional polysaccharides, amphiphlic polysaccharide derivatives
and polysaccharide-based prodrugs for biomedical applications.