Studies on Synthesis of Water-Soluble Polymer-supported Transition Metal Polypyridyl Complexes and their interaction with DNA
作者：Yun-Pu Wang, Fa-Ai Zhang, Hai-Tao Zhang and Yu-Feng Li
關(guān)鍵字：Transition metal polypyridyl complexes, Synthesis, Characterization, DNA, Interaction
論文來源：期刊
具體來源：Journal of bioactive and compatible polymers
發(fā)表時間：2010年
Five water-soluble polymer-supported transition metal polypyridyl complexes were synthesized from polyacrylic acid -co- N-vinyl pyrrolidone, 2-methyl-3-hydroxyl benzaldehyde, o-phenanthroline and metal acetate salts. Infrared spectra (IR), thermo-gravimetric and differential thermal analysis (TG-DTA), Inductance Coupling Plasma (ICP) and X-ray photoelectron spectroscopy (XPS) measurement technologies were used to characterize their composites and structures. Their interaction with DNA was studied according to fluorescent probe method and gel electrophoresis method. The results indicated that these complexes had strong interaction with DNA, there may exist other rupture mode of DNA.