Bioactive poly(4-hydroxybutyrate)/poly(ethylene glycol) fibrous dressings incorporated with zinc oxide nanoparticles for efficient antibacterial therapy and rapid clotting
作者：Shuaishuai Yuan, Xiuxia Sun, Yong Shen, and Zhibo Li*
關鍵字：antibacterial, electrospinning, hemostasis, poly(4-hydroxybutyrate) (P4HB), poly(ethylene glycol), zinc oxide
論文來源：期刊
具體來源：Macromolecular Bioscience
發表時間：2022年
Antibacterial and hemostatic properties are of great importance to wound
dressing in treating trauma. Poly(4-hydroxybutyrate) (P4HB), an U.S. Food
and Drug Administration (FDA)-approved bioabsorbable polyester, is used as
dermal substitutes to prevent sever wound contraction and improve wound
healing. However, P4HB fibrous mats are not efficient in halting bleeding and
preventing bacterial associated infection. Here the authors prepare a new kind
of wound dressing by incorporating poly(ethylene glycol) (PEG) and zinc oxide
(ZnO) nanoparticles into the P4HB matrix by using electrospinning method.
The in vitro results reveal that the P4HB/PEG/ZnO dressings can
synergistically help blood clotting, prevent bacteria adhesion, and kill bacteria
efficiently. It’s found that the bactericidal activity of the bioactive
P4HB/PEG/ZnO dressings is related to the release of Zn2+ ions rather than
reactive oxygen species (ROS) under dark condition. The in vivo antibacterial
evaluation indicates that the bioactive P4HB/PEG/ZnO dressings can
successfully prevent wound infections in Sprague–Dawley (SD) rats’ skin
defect model. The in vivo hemostatic experiments evaluated in the rabbit ear
injury model further confirm that the bioactive P4HB/PEG/ZnO dressings
have excellent hemostatic performance. Hence, this study demonstrates that
the bioactive P4HB/PEG/ZnO dressings with hemostatic and bactericidal
properties have great potential in possible clinical applications.