In vitro degradation of three dimensional porous poly(D,L-lactide-co-glycolide) scaffolds for tissue engineering
writer：Linbo Wu, Jiandong Ding*
keywords：Biodegradable polymer，Degradation， Porous scaffold， Tissue engineering， Mechanical property， Poly(d,l-lactide-co-glycolide) (PLGA)
source：期刊
specific source：Biomaterials, 25(27): 5821-5830, 2004.12
Issue time：2004年
In vitro degradation behaviors of three-dimensional tissue engineering porous scaffolds made from amorphous poly(d,l-lactideco-glycolide) with three different formulations have been systematically investigated up to 26 weeks in phosphate buffer saline solution at 37C. The following properties of the scaffolds were measured as a function of degradation time: dimensions,weight, compressive strength and modulus,polymer molecular weight and its distribution,and pore morphology. Of special interest was the determination of mechanical properties in wet environment. The pH of the PBS media was also detected. According to the
characteristic changes of the various properties of porous scaffolds,the egradation process is suggested to be roughly divided into three stages tentatively named as quasi-stable stage,decrease-of-strength stage, loss-of-weight and disruption-of-scaffold stage. 引用：145次。