[Langmuir] Supramolecular Host-Guest Interaction-Enhanced Adjustable Drug Release Based on β-Cyclodextrin-Functionalized Thermoresponsive Porous Polymer Films
作者：Yuanwei Su, Jing Dang, Haitao Zhang, Yingyi Zhang, and Wei Tian*
關鍵字：Supramolecular Host-Guest Interaction, Drug Release, Porous Polymer Films
論文來源：期刊
具體來源：Langmuir 2017, 33, 7393-7402
發表時間：2017年
Drug delivery systems based on stimuli-responsive porous polymer films (PPFs) have been extensively investigated because of their many advantages. However, the ability to adjust the drug release from PPFs is not always perfect, and at times, it cannot satisfy real-world requirements. In this paper, supramolecular host?guest interactions were harnessed to overcome the difficulties associated with adjustable release from these systems by incorporating host molecules into the pore walls of thermoresponsive PPFs. β-Cyclodextrin-functionalized porous amphiphilic block copolymer films (β-CD-PBCPFs) with controllable pore parameters, high homogeneity, and large areas were prepared by combining the self-assembly and breath-figure methods. Drug-loaded β-CD-PBCPFs displayed thermoresponsive release behavior, which could be tuned by increasing the β-CD content in phosphate-buffered saline. The release was governed by the host-guest interactions of the β-CD moieties and drug molecules. The concept of host?guest interactionenhanced adjustable release could be applied to different drug molecules, such as doxorubicin and metronidazole.
全文鏈接：
http://pubs.acs.org/doi/abs/10.1021/acs.langmuir.7b01502