In vitro degradation behavior of hydroxyapatite/poly(lactide-co-glycolide) composite reinforced by micro/nano-hybrid poly(glycolide) fibers for bone repair.
作者：Yuhang Zhu, Zongliang Wang*, Linlong Li, Daqian Gao, Qinli Xu, Qingsan
關鍵字：Nanocomposite,PLA fiber, hydroxyapatite,/poly(lactide-co-glycolide)
論文來源：期刊
具體來源：Journal of Materials Chemistry B, 2017, 5(44):8695-8706.
發表時間：2018年
A poly(glycolide) (PGA)
fiber-reinforced hydroxyapatite/poly(lactide-co-glycolide) (HA/PLGA) composite
with high mechanical strength has been prepared previously. In this paper, in
vitro degradation of ternary composites with different contents of PGA fibers
(0, 30, 50 and 70 wt%) was investigated. Water absorption showed a marked
increase as the degradation progressed, and the composite with 70 wt% PGA fibers
showed the highest final water uptake which was 3.89 times higher than the
initial value. The mass loss of the composite with 70 wt% PGA fibers was 79.3 ±
6.47% at 16 weeks, which was the highest among all the composites. The molecular
weight of the PLGA matrix decreased over time especially for the composites
containing 70 wt% PGA fibers. The lowest pH of the buffer solution was also
observed in the composite with 70 wt% PGA fibers. Environmental scanning
electron microscopy (ESEM) and micro-computed tomography (micro-CT) results
demonstrated that the porosity of the composites and the size of the pores
gradually increased as the degradation progressed. The most significant change
in compression strength was observed for the composite with 70 wt% PGA fibers
which was reduced from an initial value of 20 MPa to approximately 1 MPa at 16
weeks. The results indicated that the in vitro degradation of the composites
could be accelerated by increasing the content of PGA fibers. It implied that
the ternary composites might be a candidate for the repair of non-load bearing
or cancellous bone which needs high initial strength and fast degradation
rate.