【Applied Surface Science】Enzyme-mimicking polymer brush-functionalized surface for combating biomaterial-associated infections
作者：Rujian Jiang, Huawei Yang, Lingjie Song, Shunjie Yan, Shifang Luan*, Jinghua Yin, et al.,
關(guān)鍵字：Enzyme-mimicking polymer brush, Photografting polymerization, DNA cleavage, Antibacterial surface, Biomimetic surface
論文來(lái)源：期刊
具體來(lái)源：Applied Surface Science, 2017, 423, 869-880
發(fā)表時(shí)間：2017年
Abstract:
Biomaterial-associated infections critically compromise the functionality and performance of the medical devices, and pose a serious threat to human healthcare. Recently, natural DNase enzyme has been recognized as a potent material to prevent bacterial adhesion and biofilm formation. However, the vulnerability of DNase dramatically limits its long-term performance in antibacterial applications. In this work, DNase-mimicking polymer brushes were constructed to mimic the DNA-cleavage activity as well as the macromolecular scaffold of the natural DNase. The bacteria repellent efficacy of DNase-mimicking polymer brush-functionalized surface was comparable to that of the DNase-functionalized surface. More importantly, due to their inherent stability, DNase-mimicking polymer brushes presented the much better performance in inhibiting bacterial biofilm development for prolonged periods of time, as compared to the natural DNase. The as-developed DNase-mimicking polymer brush-functionalized surface presents a promising approach to combat biomaterial-associated infections.