Practical Syntheses of N-Acetyl (E)-β-Arylenamides.
作者：Zhihua Cai, Guodu Liu, Guangjun Jiao, Chris H Senanayake, Wenjun Tang.*
關(guān)鍵字：N-Acetyl (E)-β-Arylenamides
論文來源：期刊
具體來源：Synthesis 2013, 45, 3355-3360. (DOI: 10.1055/s-0033-1339976, communication, IF = 2.867, Citation: 3)
發(fā)表時間：2013年
A facile and practical method for the preparation of (E)-β-arylenamides [(E)-N-(1-arylprop-1-en-2-yl]acetamides] has been developed by reductive acetylation of the corresponding oximes
with iron(II) acetate as the reducing reagent. Employment of hexamethylphosphoramide as the solvent was found to be critical for the high E/Z selectivity. The methodology has been applied in efficient syntheses of a key chiral intermediate of tamsulosin by asymmetric hydrogenation.