10. Evaluation of pH-Sensitive Poly(b-amino ester)-graft-poly(ethylene glycol) and its Usefulness as a pH-Sensor and Protein Carrier
作者：Min Sang Kim, Guang Hui Gao, Seong Woo Kang, Doo Sung Lee
關鍵字：Protein delivery
論文來源：期刊
具體來源：Macromol. Biosci.
發表時間：2011年
In this study, some possible biomedical applications of a pH-sensitive and amphiphilic
copolymer as a pH sensor and protein delivery system are reported. PAE-g-PEG was used
as a pH-sensitive polymer that can exhibit a sharp pH-dependent transition. Various fluore-
scent dyes including pyrene and RITC can be used to label the pH-sensitive polymer PAE-g-PEG,
which was evaluated for protein encapsulation. pH-sensing was possible by observing
excimer formation of the labeled pyrene via pH-dependent expansion of the polymeric
chain. Also, it was confirmed that FITC-BSA could be entrapped in RITC-labeled pH-sensi-
tive micelles of PAE-g-PEG by FRET. As a result,
PAE-g-PEG can be a pH sensor and carrier for
protein delivery.