[Acs Appl Mater Interfaces] Bioinspired Antioxidant Defense System Constructed by Antioxidants-Eluting Electrospun F127-Based Fibers
作者：Haozheng Wang, Shi Qiang et al.
關鍵字：自適應性，抗氧化性表面
論文來源：期刊
具體來源：ACS Appl. Mater. Interfaces 2017, 9, 38313-38322
發表時間：2017年
Cells were continuously exposed to oxidative damage by overproduction
of reactive oxygen species (ROS) when they contacted implanted
biomaterials. The strategy to prevent cells from oxidative injures remains a
challenge. Inspired by the antioxidant defense system of cells, we constructed a
biocompatible and ROS-responsive architecture on the substrate of styrene-b-
(ethylene-co-butylene)-b-styrene elastomer (SEBS). The strategy was based on
fabrication of architectures through reactive electrospinning of mixture including
SEBS, acylated Pluronic F127, copolymer of poly(ethylene glycol) diacrylate and
1,2-ethanedithiol (PEGDA?EDT), and antioxidants (AA-2G) and ROS-triggered
release of AA-2G from microfibers to detoxify the excess ROS. We demonstrated
that the stable and hydrophilic architecture was constructed by phase separation of
SEBS/F127 components and cross-linking between polymer chains during
electrospinning; the ROS-responsive fibers controlled the release of AA-2G and
the interaction of AA-2G with ROS reduced the oxidative damage to cells. The
bioinspired architecture not only reduced mechanical and oxidative damage to cells but also maintained normal ROS level for physiological hemostasis. This work provides basic principles to design and develop antioxidative biomaterials for implantation in
vivo.